Package validation1 years ago
Guide to running the validation suite | Adding a signature page | References
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Bias adjustment - methods for discounting of phase II results2 years ago
The example setting | Applying the package to the example | Interpreting the output | Where to go from here | References
Binary outcome variables2 years ago
The example setting | Applying the package to the example | Defining all necessary parameters | Interpreting the output | Where to go from here
Fixed effect estimates and prior distributions2 years ago
The example setting | Parameters of the prior distribution | Interpreting the output | Prior distributions for time-to-event outcomes | Where to go from here
Interpreting the rest of the output2 years ago
The example setting and the input parameters | Interpreting the output | Where to go from here
Multiarm - methods for multi-arm programs2 years ago
The example setting | Applying the package to the example | Defining all necessary parameters | Interpreting the output | Where to go from here
Multiple - methods for trials with multiple endpoints2 years ago
Only one endpoint has to be significant | Defining all necessary parameters | Interpreting the output | Both endpoints have to be significant | Where to go from here
More parameters to adapt to specific settings2 years ago
The example setting and the input parameters | Fixed treatment effect estimates or prior distributions | Constrained optimization | Cost constraint -- maximum total costs | Sample size constraint -- maximum number of participants | Success probability constraint - minimum probability of a successful program | Customized effect size categories | Differences in the treatment effect | Skipping phase II | Parallel computing | Where to go from here | References
Multitrial - methods for programs with several phase III trials2 years ago
The example setting | Applying the package to the example | Interpreting the output | Where to go from here | References
Time-to-event outcome variables2 years ago
The example setting | Applying the package to the example | Defining all necessary parameters | Interpreting the output | Where to go from here
Introduction to planning phase II and phase III trials with drugdevelopR3 years ago
The example setting | Applying the package to the example | Defining all necessary parameters | Interpreting the output | Where to go from here
